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Manic Depression and Genetics

Research into manic depression, more less behavior traits that could be called
formally called bipolar disorder, has despair-type behavior. These mice
been hindered, according to many in the without the GluR6 also displayed more
scientific community due to the lack of aggressive behavior, another character
animal models upon which to base studies. trait of a manic episode of manic
Until now that is. Scientists have been depression.
able to create a genetically engineered The scientists also administered
defect in a specific gene which may play biochemical tests on these mice, the
a leading role in causing mood disorders, results of which suggested that the GluR6
like manic depression. The gene is known gene may also play a unique role in
as glutamate receptor 6 - referred to as actually regulating some of the symptoms
GluR6 - and has long been associated with of mania.
manic depression. Now that researchers have genetically
Scientists knew that the gene was related engineered this type of laboratory mouse,
to manic depression but were unsure of they'll be better able to study manic
the exact mechanism. Not only that, but depression. This study also opens the
the gene encoding for the GluR6 receptor door for further studies that may very
has not only been linked to manic well lead to new treatments.
depression, but also to the tendency of Manic depression is a mental health
some individuals to consider suicide disorder characterized by erratic swings
while taking antidepressant drugs in a in mood. Individuals with this health
separate pharmacogenetic study. issue, most recently renamed bipolar
Interestingly enough, individuals who disorder, are subject not only to
suffer with manic depression are the most depression, but also episodes of mania.
susceptible to antidepressant-induced These manic episodes involve high energy
states of restlessness. expenditure, sleeplessness for several
In the new study, scientists utilized days sometimes, as well as rapid speech,
mice to further examine the issue. The racing thoughts and feelings of
scientists used mice with the GluR6 gene grandiosity. Those individuals
missing, comparing them to a control experiencing a manic episode may also
group of mice who had the gene. display psychotic behavior, such as
Both groups of mice underwent a series of hallucinations.
tests specifically created to imitate the Several mood stabilizing drugs are
symptoms of manic episode of manic currently available for the treatment of
depression. The researchers discovered manic depression. Individuals with manic
that the mice with the Glu6R gene missing depression are also encouraged to take a
displayed many of the symptoms of mania. series of behavioral therapy as well.
Not only were these mice more active in For more resources regarding bipolar or
several tests, they also displayed more even about symptom of bipolar disorder
anxiety and more behavior traits that and especially about bipolar medication
could be classified as risk taking and please review these pages.




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