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Manic Depression and Genetics

Research into manic depression, morecould be classified as risk taking and
formally called bipolar disorder, hasless behavior traits that could be
been hindered, according to many in thecalled despair-type behavior. These
scientific community due to the lack ofmice without the GluR6 also displayed
animal models upon which to basemore aggressive behavior, another
studies.character trait of a manic episode of
Until now that is. Scientists have beenmanic depression.
able to create a genetically engineeredThe scientists also administered
defect in a specific gene which may playbiochemical tests on these mice, the
a leading role in causing moodresults of which suggested that the
disorders, like manic depression. TheGluR6 gene may also play a unique role
gene is known as glutamate receptor 6 -in actually regulating some of the
referred to as GluR6 - and has long beensymptoms of mania.
associated with manic depression.Now that researchers have genetically
Scientists knew that the gene wasengineered this type of laboratory
related to manic depression but weremouse, they'll be better able to study
unsure of the exact mechanism. Not onlymanic depression. This study also opens
that, but the gene encoding for thethe door for further studies that may
GluR6 receptor has not only been linkedvery well lead to new treatments.
to manic depression, but also to theManic depression is a mental health
tendency of some individuals to considerdisorder characterized by erratic swings
suicide while taking antidepressantin mood. Individuals with this health
drugs in a separate pharmacogeneticissue, most recently renamed bipolar
study.disorder, are subject not only to
Interestingly enough, individuals whodepression, but also episodes of mania.
suffer with manic depression are theThese manic episodes involve high energy
most susceptible toexpenditure, sleeplessness for several
antidepressant-induced states ofdays sometimes, as well as rapid speech,
restlessness.racing thoughts and feelings of
In the new study, scientists utilizedgrandiosity. Those individuals
mice to further examine the issue. Theexperiencing a manic episode may also
scientists used mice with the GluR6 genedisplay psychotic behavior, such as
missing, comparing them to a controlhallucinations.
group of mice who had the gene.Several mood stabilizing drugs are
Both groups of mice underwent a seriescurrently available for the treatment of
of tests specifically created to imitatemanic depression. Individuals with
the symptoms of manic episode of manicmanic depression are also encouraged to
depression. The researchers discoveredtake a series of behavioral therapy as
that the mice with the Glu6R genewell.
missing displayed many of the symptomsFor more resources regarding bipolar or
of mania.even about symptom of bipolar disorder
Not only were these mice more active inand especially about bipolar medication
several tests, they also displayed moreplease review these pages.
anxiety and more behavior traits that



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